Найдено научных статей и публикаций: 1, для научной тематики: Rodent carcinogens
1.
Lagunin A., Filimonov D., Zakharov A., Xie W., Huang Y., Zhu F., Shen T., Yao J., Poroikov V.
- QSAR and Combinatorial Science , 2009
Computer-aided prediction of rodent carcinogenicity for the external test set consisting of 293 chemicals was performed by PASS (Prediction of Activity Spectra for Substances)
and by CISOC-PSCT. The set included 64 carcinogens from ISS Carcinogens Data Bank
and 229 noncarcinogens from the Prestwic...
Computer-aided prediction of rodent carcinogenicity for the external test set consisting of 293 chemicals was performed by PASS (Prediction of Activity Spectra for Substances)
and by CISOC-PSCT. The set included 64 carcinogens from ISS Carcinogens Data Bank
and 229 noncarcinogens from the Prestwick Chemical Library. We calculated the accuracy
of carcinogenicity prediction by PASS and CISOC-PSCT in apart, and by the two programs together (the consensus model). Sensitivity, specificity and accuracy (concordance) were calculated for the external test set by PASS (0.81, 0.74, 0.76), by CISOC-PSCT (0.36, 0.89, 0.77) and by the consensus model (0.69, 0.86, 0.83). Thus, taking
into account the prediction results of two computer programs for rodent carcinogenicity
the consensus model increases the accuracy of prediction.
QSAR and Combinatorial Science, 2009, 28 (8) 806-810.
