Связанные научные тематики:

 Найдено научных статей и публикаций: 1, для научной тематики: PKCe


Thienoquinolines as novel disruptors of the PKCe/RACK2 protein-protein interaction (публикация автора на scipeople)     

Rechfeld F, Gruber P, Kirchmair J, Boehler M, Hauser N, Hechenberger G, Garczarczyk D, Lapa GB, Preobrazhenskaya MN, Goekjian P, Langer T, Hofmann J. - J Med Chem. , 2014
ABSTRACT: Ten protein kinase C (PKC) isozymes play divergent roles in signal transduction. Because of sequence similarities, it is particularly difficult to generate isozyme-selective small molecule inhibitors. In order to identify such a selective binder, we derived a pharmacophore model from the p...