Data on application of decellularized scaffolds and tissue-engineered vascular conduits in the field of cardiovascular surgery have been analyzed, and also techniques for their procurement have been studied. For finding, selection and synthesis resources of research data from the systems Pubmed, ScienceDirect were used. The preference was given to the most informative, comprehensive and contemporary publications.
Brumberg V.A., Lauk-Dubitsky S.E., Astrelina Т.А., Kobzeva I.V., Bushmanov A.Y., Samoilov A.S. Analysis of production of the decellularized scaffolds and their potential use in cardiovascular surgery // Saratov Journal of Medical Scientific Research, Vol. 11, Issue 4, 2015, pp. 615-620

In the present study, a series of benzimidazole derivatives were synthesized in domestic microwave oven as well as by conventional procedures. These benzimidazole derivatives were also screened for insecticidal activity by MES (maximum electroshock) method. Most of these biologically active compounds were free of toxicity in irritation, sensitivity and immunology. The structures of all synthesized compounds have been determined by FTIR and 1H NMR spectral methods.

The saturated nitrogen-containing heterocyclic compounds include many drugs and compounds that may be used as synthons for the synthesis of other pharmacologically active substances. The need for new derivatives of saturated nitrogen-containing heterocycles for organic synthesis, biotechnology and the pharmaceutical industry, including optically active derivatives, has increased interest in microbial synthesis. This review provides an overview of microbial technologies that can be valuable to produce new derivatives of saturated nitrogen-containing heterocycles, including hydroxylated derivatives. The chemo-, regio- and enantioselectivity of microbial processes can be indispensable for the synthesis of new compounds. Microbial processes carried out with fungi, including Beauveria bassiana, Cunninghamella verticillata, Penicillium simplicissimum, Aspergillus niger and Saccharomyces cerevisiae, and bacteria, including Pseudomonas sp., Sphingomonas sp. and Rhodococcus erythropolis, biotransform many substrates efficiently. Among the biological activities of saturated nitrogen-containing heterocyclic compounds are antimicrobial, antitumor, antihypertensive and anti-HIV activities; some derivatives are effective for the treatment and prevention of malaria and trypanosomiasis, and others are potent glycosidase inhibitors.
Appl. Microbiol. Biotecnol. 2014. V.98. N 4. P. 1497-1506.

A series of 2-arylhydroxynitroindoles were prepared and tested for antifungal activity in vitro. The preliminary bioassays indicated that some compounds are comparable to the commercial fungicide (triadimefon). To further explore the structureeactivity relationships, the data set of the seventeen structures and their quantitative values of antifungal activities were used for QSAR modeling. Based on the obtained QSAR models four new chemical compounds were designed, synthesized and tested in fungicidal assays. Reasonable correspondence between the experimental and predicted values of antifungal activity was observed.
Eur. J. Med. Chem., 2011, 46 (9), 4374-4382.

С целью решения задачи синтеза диагностических моделей разработаны методика и программные средства («Автоматизированная система синтеза нейросетевых и нейро-нечетких моделей для неразрушающей диагностики и классификации образов по признакам», «Автоматизированная система эволюционного синтеза и оптимизации диагностических моделей», «Мультиагентная система построения и оптимизации прецедентно-ориентированных моделей для поддержки принятия решений»), позволяющие автоматизировать построение диагностических моделей по прецедентам на основе нейро-нечетких сетей. In order to solve the problem of diagnostic model synthesis the methodology and software («Automated system of neural network and neuro-fuzzy model synthesis for non-destructive diagnosis and pattern classification on the features», «Automated system of evolutionary synthesis and optimization of diagnostic models», «Multi-agent system for constructing and optimization of case-oriented models for decision support») have been developed to automate the diagnostic model building on precedents on the basis of neuro-fuzzy networks.

Synthesis of philosophy by the new concept of materialistic determinism and monism. Materialism Revised by Ring Determinism.

Synthesis of philosophy by the new concept of materialistic determinism and monism. Materialism Revised by Ring Determinism.

Acyl derivatives of 2-aminopyridine, 2-aminopyrimidine, 4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl, and 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl were obtained from long-chain diacetylenic acyl chlorides and the corresponding heterocyclic compounds. Spreading isotherms of monolayers on a water surface show that lengthening of the hydrocarbon chain and replacement of the pyridyl groups in these compounds by the more hydrophilic pyrimidyl groups render the films more condensed. Long-chain acyl derivatives of nitroxyl radicals form monolayers possesing a low collapse pressure. ESR spectra of Langmuir-Blodgett films of these radicals before and after photopolymerization were recorded.
Russ.Chem.Bull. 1995, V.44, No.10, pp. 1929-1932

Methods of synthesising stable 2-imidazoline nitroxides linked to a pyrazole moiety either directly or through a phenylethynylic bridge have been developed; an unusually strong temperature dependence of μeff for 2-(1-methylpyrazolyl-5)-4,4,5,5-tetramethyl- 1-oxyl-2-imidazoline-3-oxide is observed.
Mendeleev Comm., 1998, V.8, No.6, pp.207–209

Present review describes research on novel natural cyclobutane-containing alkaloids isolated from terrestrial and marine species. More than 60 biological active compounds have been confirmed to have antimicrobial, antibacterial, antitumor, and other activities. The structures, synthesis, origins, and biological activities of a selection of cyclobutanecontaining alkaloids are reviewed. With the computer program PASS some additional biological activities are also predicted, which point toward new possible applications of these compounds. This review emphasizes the role of cyclobutane-containing alkaloids as an important source of leads for drug discovery.
The Open Medicinal Chemistry Journal, 2008, 2, 26-37.