Purpose: to study biochemical indices of peripheral blood which show organs functional changes. Material and Methods. The experiments were carried out on white mice in dynamics development of pseudomonas aeruginosa caused by intraperitoneal injection of various dosage of exotoxin A. Results. The dosage-dependent disturbances in activity of transaminases, a-HBDH, in content of proteins, lipids and cholesterol were revealed. The received data have determined the hepatotoxic effect of pseudomonas aeruginosa exotoxin A on changes of biochemical blood markers of liver function. Conclusion. The expressed hepatotoxic effect of Pseudomonas aeruginosa exotoxin A has been determined during all the phases of experiment even at sublethal toxin dose.
Morrison A.V., Popovich V.I., Morrison V.V. Pseudomonas aeruginosa exotoxin A-induced hepatotoxicity in dynamics: an animal model in white mice // Saratov Journal of Medical Scientific Research, Vol. 11, Issue 4, 2015, pp. 526-529

The aim of the article is to present the data analysis of the Russian and foreign literature concerning the current situation of the problem, the frequency and mechanisms of pseudomonas infection development and factors of patho-genicity of Pseudomonas aeruginosa. The mechanisms of exotoxin A effect have been under the study
Morrison A.V., Popovich V.I., Morrison V.V.. Pseudomonas infection: exotoxin A effect // Saratov Journal of Medical Scientific Research, Vol. 10, Issue 3, 2014, pp. 542-546