The review deals with the diagnosis of changes in bone metabolism in children with juvenile idiopathic arthritis (JIA) in terms of disclosure of the pathogenetic mechanisms of immunopathological disorders in the body. It is shown that timely and adequate characterization of the state of mineralization of bone tissue in patients with JIA — as an indicator of systemic catabolic process, remains an ongoing problem, entailing the need for large-scale introduction of new diagnostic techniques. Through the presentation of the traditional methods of diagnosis of bone metabolism, their capabilities, strengths and weaknesses, analyze the advantages of assessing the level of bone formation, taking into account a variety of biochemical markers. The data on the development of modern diagnostic approaches to the assessment of osteopenia complications in children with JIA, based on the characterization of molecular-genetic targets of the process of osteogenesis. Conclusion: for the adequate therapy and its timely correction in children with JIA in the early stages of the disease it is necessary to carry out a comprehensive study on the identification of metabolic disorders of bone, holding it in the dynamics, and actively introducing the practice of modern and affordable methods of diagnosis of osteopenic disorders.
Spivakovskaya A.Y., Chernenkov Y.V., Spivakovsky У.М. Modern aspects of diagnosis of bone metabolism in children with juvenile idiopathic arthritis // Saratov Journal of Medical Scientific Research, Vol. 10, Issue 3, 2014, pp. 422-427