Aim — The main focus of the project was to identify whether there is any interaction between Ketotifen Fumarate (antihistamine) and domperidone (Antiemetic/dopaminergic antagonist) present or not at simulated gastric and intestinal solutions of different pH. Methods — Using Job’s continuous-variation analysis the possible drug-drug interaction was determined at a fixed temperature (37ºC) at the studied pH. From Job’s continuous-variation analysis the views of drug-drug interaction at different concentration ratio at all pH (0.4, 1.2, 2.0, 2.8, 6.8, and 7.4) except 6.0 were noted. Results — Data obtained from spectroscopic analysis showed decrease in free-drug concentration of both of the drugs analyzed when they were within the same gastric simulated solution. Conclusion — Concurrent administration of Ketotifen Fumarate and domperidone would result in the formation of a stable complex and this is likely to reduce the the rapeutic activities of both drugs.
Mohammad Aktar Sayeed, Fuad Mohammed Farhad, Syed Mohammed Tareq, Md. Ikram, Md. Nurul Islam, Saiful Alam Siddique, Dipesh Das A study of in-vitro interaction of Ketotifen Fumarate with Domperidone at different gastric and intestinal pH // Russian Open Medical Journal, Vol. 3, Issue 2, 2014, pp. 204-0