The peculiarities of drugs used for asthma treatment in various historical periods are discussed. Introduction of drugs into clinical practice, including muscarinic receptor antagonists, b2-adrenoreceptor agonists, methylxanthines, cromones, and glucocorticoids is analyzed. Special attention is devoted to cysteinyl leukotriene receptor antagonists and immunobiological agents.

Aim: to evaluate the efficacy of pharmacotherapy of bronchial asthma in children with concomitant correction of magnesium deficiency. Material and Methods. A 12-week, prospective, randomized, open, comparative, parallel-group, which was included in the 50 children with uncontrolled and partially controlled atopic asthma and laboratory-confirmed magnesium deficiency. For the groups 1 and 2 it was assigned basic therapy of asthma in accordance with the recommendations of GINA (2011). In the group 1 it had been additionally performed concomitant correction of magnesium deficiency of Magnesium B6 Forte. There had been evaluated the effectiveness of a drug therapy for 12 weeks on the achieved level of asthma control, the frequency of exacerbations, the number of asymptomatic days. Dynamics of the severity of allergic inflammation was assessed by monthly monitoring of levels of nitric oxide in exhaled air (FeNO). Results. After 12 weeks of treatment, the magnesium content in erythrocytes in group 1 (1.79 (1,68-1,89) mmol / L) increased by 15.7% and was statistically significant (p <0,001) differed from group 2 (1.63 (1.57-1.68) mmol /L). By the end of the study the number of controlled asthma episodes in group 1 was significantly (p = 0.038) larger (20/25) than in group 2 (12/25), and the content of FeNO (19 (13-24) ppb) — significantly less (p = 0.013) than in control group (25 (21-30) ppb). Conclusion. The efficacy of pharmacotherapy of bronchial asthma in children is increased by the background correction of magnesium deficiency.
Shishimorov I.N., Perminov А.А., Nefedov I.V. The assessment of bronchial asthma pharmacotherapy effectiveness on the background correction of magnesium deficiency in children // Saratov Journal of Medical Scientific Research, Vol. 10, Issue 1, 2014, pp. 211-214

effectiveness of basic therapy for atopic asthma in children. Material and Methods. A 24-week, prospective, comparative, randomized, open-label study in parallel groups was performed. There were included 70 children with uncontrolled atopic asthma with high FeNO (FeNO>50ppb). There were evaluated the comparative efficacy of selection of basic therapy by using monthly monitoring of FeNO and criteria of asthma control in accordance with the recommendations of GINA (2011). Results. The cost / effective ratio (CER) for achievement of one permanent 12 week-control after 24 weeks of therapy in group of monitoring FeNO was 11433,26 rubles, which was 40% lower, than the CER in the comparison group (18382,99 rubles). Conclusion. The using of FeNO monitoring for a personalized correction of basic therapy in children with uncontrolled atopic asthma can reduce the cost of treatment and is also economically viable.
Petrov V.I., Shishimorov I.N., Magnitskaya O.V., Ponomareva Ju.V. Pharmacoeconomic efficiency of the exhaled nitric oxide monitoring for the purpose of personalized basic therapy for children with atopic asthma // Saratov Journal of Medical Scientific Research, Vol. 10, Issue 1, 2014, pp. 196-199