In this research the entropy characteristics of natural polypeptide sequences are studied. Based on these results suggested a new paradigm of the structural organization of proteins. Elementary unit in sequence of protein according to this new paradigm is the group of five neighboring residues. Such a group of five neighboring residues has been called the "information unit". The method of analysis of the information structure (ANIS method) was developed based on this paradigm. ANIS method was enabling to disclose the hierarchical organization of structural information contained in amino acid sequence of proteins. Applications of ANIS method in protein engineering, studies of structural organization of enzymes and protein-protein complexes are described.
The Conference “Theoretical Approaches to BioInformation Systems - TABIS 2013”. p.1