Aim: the study of the physical effect of the local dose increasing in biological tissue at the gadolinium-containing drug under the influence of X-ray radiation. Material and Methods. Experimental and three independent numerical methods are obtained distribution of the absorbed dose in tissue-equivalent phantom containing a model of the tumor with a given concentration of gadolinium. Results. The presence of a gadolinium-containing drug in the biological tissue (1% Gd by weight) leads to a local increase of an absorbed dose up to 2 times under the influence of X-ray radiation. The difference in the results obtained calculated and experimental methods does not exceed 12%. Conclusion. The results of the study confirmed the basic theoretical background photon capture therapy, as well as the legal use of methods of mathematic modeling of the process of forming radiation in biological tissue, necessary for dosimetric photon capture therapy planning.
Sheino I.N., Izhevskij P. W., Lipengolts A.A. Background of photon-capture therapy principle of malignant cancer treatment // Saratov Journal of Medical Scientific Research, Vol. 9, Issue 4, 2013, pp. 878-881