Background GLORIA-AF (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation) is a prospective, global registry program describing antithrombotic treatment patterns in patients with newly diagnosed nonvalvular atrial fibrillation at risk of stroke. Phase 2 began when dabigatran, the first non–vitamin K antagonist oral anticoagulant (NOAC), became available. Objectives This study sought to describe phase 2 baseline data and compare these with the pre-NOAC era collected during phase 1. Methods During phase 2, 15,641 consenting patients were enrolled (November 2011 to December 2014); 15,092 were eligible. This pre-specified cross-sectional analysis describes eligible patients’ baseline characteristics. Atrial fibrillation disease characteristics, medical outcomes, and concomitant diseases and medications were collected. Data were analyzed using descriptive statistics. Results Of the total patients, 45.5% were female; median age was 71 (interquartile range: 64, 78) years. Patients were from Europe (47.1%), North America (22.5%), Asia (20.3%), Latin America (6.0%), and the Middle East/Africa (4.0%). Most had high stroke risk (CHA2DS2-VASc [Congestive heart failure, Hypertension, Age ≥75 years, Diabetes mellitus, previous Stroke, Vascular disease, Age 65 to 74 years, Sex category] score ≥2; 86.1%); 13.9% had moderate risk (CHA2DS2-VASc = 1). Overall, 79.9% received oral anticoagulants, of whom 47.6% received NOAC and 32.3% vitamin K antagonists (VKA); 12.1% received antiplatelet agents; 7.8% received no antithrombotic treatment. For comparison, the proportion of phase 1 patients (of N = 1,063 all eligible) prescribed VKA was 32.8%, acetylsalicylic acid 41.7%, and no therapy 20.2%. In Europe in phase 2, treatment with NOAC was more common than VKA (52.3% and 37.8%, respectively); 6.0% of patients received antiplatelet treatment; and 3.8% received no antithrombotic treatment. In North America, 52.1%, 26.2%, and 14.0% of patients received NOAC, VKA, and antiplatelet drugs, respectively; 7.5% received no antithrombotic treatment. NOAC use was less common in Asia (27.7%), where 27.5% of patients received VKA, 25.0% antiplatelet drugs, and 19.8% no antithrombotic treatment. Conclusions The baseline data from GLORIA-AF phase 2 demonstrate that in newly diagnosed nonvalvular atrial fibrillation patients, NOAC have been highly adopted into practice, becoming more frequently prescribed than VKA in Europe and North America. Worldwide, however, a large proportion of patients remain undertreated, particularly in Asia and North America. (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients With Atrial Fibrillation [GLORIA-AF]; NCT01468701)

The aim of the study is to describe the development of the algorithm for the data analysis of Russian coronary artery disease (CAD) Registry. The algorithm allows determining the need in percutaneous coronary intervention (PCI) and evaluation the validity of PCI in patients with stable CAD on the basis of appropriate use criteria for coronary revascularization by the American College of Cardiology. Two measures propose for clinical decision support and automated assessment of PCI appropriateness «The need in PCI in patients with stable CAD» and «PCI validity in patients with stable CAD».
Genkal E.N., Posnenkova О.М., Kiselev A.R., Korotin A.S., Gridnev V.I., Dovgalevsky P.Ya. Perspectives of anatomical and clinical criteria use in revascularization of patients with stable coronary artery disease // Saratov Journal of Medical Scientific Research, Vol. 11, Issue 3, 2015, pp. 280-286

Aims: radiation accidents analysis in which there has been an uneven exposure of a human body. Material and Methods. The Burnazyan FMBC Radiation Accidents Register information and published data in other countries are investigated. Results. The Radiation Accidents Register of State Scientific Research Center n.a. A. I. Burnasyan consist the full information of radiation accidents in the former USSR (1949-1991) and the Russian Federation (1992-2012) territory. There is an evidence of 39 radiation accidents with 190 victims with a diagnosis of acute radiation syndrome and uneven exposure (incl. 4 episodes after 1991 in Russia), 62 people of which (incl. one in 1997 in Russia) died in the acute phase. Conclusion^ Experience in the treatment of such victims, which are available from the State Scientific Research Center n.a. A. I. Burnazyan staff, is comparable with the total experiences in other developed countries.
Soloviev V.Yu., Barabanova A.V., BushmanovA.Yu. Radiation accidents with uneven exposure // Saratov Journal of Medical Scientific Research, Vol. 9, Issue 4, 2013, pp. 901-905

Aim: the analysis of epidemiological monitoring of Parkinson's disease. Material and Methods. We conducted the full-design population study in the six closed administrative-territorial unit (Seversk, Zarechniy, Ozersk, Lesnoy, Sarov and Zheleznogorsk) with an adult's population about 450000 in the period from 2009 to 2012. For collecting information was developed the register of PD. Results. 588 patients with PD were revealed and enrolled, including 302 patients, who were revealed in the first. Primary morbidity was 11.0 per 100000 population in 2009, and in 2010 and 2011 it was 25.7 and 22.7 per 100000 population respectively. By the beginning of 2012 was so-called "dredging" of patients from population (revealing of all patients, who were not revealed earlier) and was 8.5 per 100000. Total morbidity for 4 years of observation increased: so in 2009 it was 33.1 per 100000, in 2010-92.5 per 100000, in 2011-114,2 per 100000, and in 2013-118,7 per 100000, the same like international data. The Evolution of sex and age structure according to the Register's data showed: 1) peak of morbidity at age 70-74 years, with the decay over 85 years; 2) morbidity was higher in men aged 70-74 years and older. Conclusion. Implementation of the Register of PD's patients annually allowed to monitoring of the morbidity and statistically significant show the basic epidemiological evidence and undertake federal and sampling comparative studies, it is necessary for evaluation of the changes of Parkinson's disease status, which can't be done on the basis of the state statistical dates.
Krivonos О.V., Smolentseva I.G., Amosova N.A. Epidemiological monitoring the of Parkinson's disease morbidity // Saratov Journal of Medical Scientific Research, Vol. 9, Issue 4, 2013, pp. 873-877

Aim: to develop and implement of the order of the dispensary observation of Parkinson's disease patients. Material and methods, the dispensary observation of Parkinson's disease patients had been performed by neurologist and diagnostic room (CDR) based on the outpatient department of health care institutions obeyed by FMBA of Russia in six Closed Administrative-Territorial Units: Seversk, Zarechniy, Ozersk, Lesnoy, Sarov and Zheleznogorsk. Neurologist examined of patients and put data to the Register's database. Register's database had 588 Parkinson's disease examined patients, 112 of them (19,1%) had stage II of the disease by Hoehn and Yahr, 231 (39,3%) patients — stage III by Hoehn and Yahr, 187 (31,8%) patients — stage IV byHoehn and Yahr, 58 (9,9%) patients — stage V by Hoehn and Yahr. The duration of the dispensary observation of Parkinson's disease patients was 4 years (2009-2012). Results. There are and implement the order of the observed and accounting of adult's group of Parkinson's disease patients were developed, who are registered in the clinical and diagnostic rooms, including the frequency of physician's visits, the list of diagnostic and treatment activities and efficiency endpoint of the dispensary observation. Conclusion. Implementation of the order of the dispensary observation according to the Register allowed to identify the main disabling PD's symptoms (depression, dementia, motor fluctuations and dyskinesia) and timely correction of therapy.
Krivonos О.V., Smolentseva I.G., Amosova N.A., Chupina L.P. Principles of dispensary observation of patients with Parkinson's disease in a specialized clinical diagnostic room // Saratov Journal of Medical Scientific Research, Vol. 9, Issue 4, 2013, pp. 869-873