Objective: to carry out the comparative efficacy evaluation of various immunohistochemical markers in stage definition and prognosis of muscle-invasive urinary bladder cancer. Material and methods. Surgical material has included 80 patients with urinary bladder neoplasms. Clinical, histological, immunohistochemical and statistical methods of research has been used. Results. The immunohistochemical investigation has showed that only 4 markers from the 12 (Ki-67, рбЗ, p53 и EGFR) make possible to determine the stage of urinary bladder cancer and the disease prognosis. Conclusion. The proliferative activity of marker Ki-67 can be used as an auxiliary marker in the choice of volume of surgical treatment, which could predict an unfavorable outcome of disease in 81,2% of cases.
Ponukalin A.N., Maslyakova G.N., Tsmokalyuk E.N. Efficacy evaluation of various immunohistochemical markers in stage definition and prognosis of muscle invasive urinary bladder cancer // Saratov Journal of Medical Scientific Research, Vol. 10, Issue 1, 2014, pp. 124-128

Purpose: to establish efficiency of a range of uric and serum biomarkers of bladder cancer for diagnostics and the prognosis of risk of development of disease recurrence. Material and methods: TPA and TPS, VEGF level research in blood serum, UBC in urine in 176 people, among which 135 patients with bladder cancer (RMP) have been conducted. Group of comparison has included16 patients (patients with cystitis). The control group has been made of 25 almost healthy men. 75 patients had non-muscle invasive RMP (Ta-1N0M0). Results. It has been statistically determined that reliable growth of of TPA, TPS in blood serum and UBC in urine in patients with non-muscle invasive RMP in comparison with patients in groups of control and comparison has been established. The increase of UBC in urine of patients of this group with recurrence of tumoral growth within a year has been noted. In comparison with cytological research of urine sedimentation, molecular markers of RMP (the uric UBC and serum TPA, TPS) possess diagnostic sensitivity, allow to confirm the presence of disease, to carry out diagnostics of stages of organ and extra invasion. RMP is possible to consider as an additional prognostic serum marker increase in the VEGF level in blood serum. Conclusion. Inclusion in diagnostic process in the clinical research of biomarkers showed that identification of NMIRMP increased from 18,1% in 2006 to 55,6% in 2011. The chosen volume of complex treatment allowed to reduce recurrence and lethality in the first two years from 32 to 15,5%.
Popkov V.M., Ponukalin A.N. Zakharova N.B. Assessment of range of uric and serum biomarkers in determination of bladder cancer severity // Saratov Journal of Medical Scientific Research, Vol. 9, Issue 4, 2013, pp. 735-740