Найдено научных статей и публикаций: 1, для научной тематики: Ischemia-reperfusion injury
1.
Galagudza M.M., Blokhin I.O., Shmonin A.A., Mischenko K.A.
- Cardiovasc Hematol Disord Drug Targets , 2008
Abstract: Reduction of infarct size as well as alleviation of other ischemia- and reperfusion-associated injuries are the
goals of primary importance in cardiology. One of the remedies is considered to be myocardial preconditioning (PreCon)
referred usually to as an increased myocardial tolerance to...
Abstract: Reduction of infarct size as well as alleviation of other ischemia- and reperfusion-associated injuries are the
goals of primary importance in cardiology. One of the remedies is considered to be myocardial preconditioning (PreCon)
referred usually to as an increased myocardial tolerance to prolonged ischemia following brief ischemic or non-ischemic
challenge. In this review, PreCon stimuli tested to date are considered including a number of mildly noxious factors applied
either locally to the myocardium or systemically. Recently, one more mode of heart protection against reperfusion
injury termed postconditioning (PostCon) has been developed. On the basis of ample evidence published, along with our
findings, a detailed comparative analysis of PreCon and PostCon is presented, with special emphasis on the cellular, molecular,
and pharmacological aspects of the topic as well as clinical applications, both implemented and awaiting practical
approval.
Cardiovasc Hematol Disord Drug Targets. 2008 Mar; 8(1): P.47-65.