Aim: development of criteria and a method of prognosing of emergence of adverse side effects to the first mode of chemotherapy at patients with for the first time revealed tuberculosis. Materials and Methods: The analysis of the collateral reactions (CR) on tubercular preparations has been carried out at 214 patients receiving treatment at the first mode of chemotherapy. During the treatment an indicator of quality of life by a technique the DIGNITY (health, activity, mood), a condition of intersystem interaction of respiratory and cardiovascular systems of an organism (Hildebrant's coefficient), a vegetative index of Kerdo were estimated at patients. Results. Ufavorable effects on PTP develop at every third patient (33,6%). The CR different types depends on the age and availability of the accompanying pathology. Allergic reactions develop at patients with existence of endocrine pathology (27,8%) authentically more often, toxic — at patients with defeats of nervous system (56,3%). Extent of change of an index of Kerdo of 59,4±2,4%, Hildebrant's coefficient 48,9± 1,6% in the first 4 weeks of treatment of the patient corresponds to emergence of CR in the first 3 months of chemotherapy. Conclusion. Dynamics of coefficient of Hildebrant, Kerdo's index and an indicator of treatment, SAN at the initial stages, are considerably associated with the risk of development of side effects of chemotherapy and were a basis of the developed computer system expert for prognosing the development of these complications. The predictive value of system is 76,3% of sensitivity at 84,7% of specificity.
Danilov A.N., Morozova T.l., Doktorova N.P. Prognosis of development of unfavorable phenomena of chemotherapy in patients with for the first time revealed tuberculosis of lungs // Saratov Journal of Medical Scientific Research, Vol. 11, Issue 4, 2015, pp. 576-582

The aim: To determine the nature and frequency of side effects observed on acitretin therapy of patients with severe forms of psoriasis. Materials and methods. The study included 20 patients with generalized pustular psoriasis. Due to the inefficiency of the ongoing standard therapy, in addition to the plan of treatment, all patients were included systemic retinoid — acitretin (neotigazon) at a dose of 0,3-0,5 mg/kg per day. I control group consisted of patients with psoriasis receiving standard therapy without the use of systemic retinoids. II control group consisted of patients taking acitretin about keratosis. Results. In 18 patients of the main group noted the development of side effects, such as xerosis and nail fragility. In 14 patients of the main group and 3 patients of the II control group the results of urinalysis tests and Nechiporenko sample were detected by elevated levels of red blood cells and the development of hematuria. Conclusion. The study found that 17 patients had development of hematuria, which can be considered regarded as a side effect of acitretin therapy.
Slesarenko N.A., Bakulev A.L., Shabogina A.A., Platonova A.N., Utz S.R., Markina M.V., Shtoda U.M. Side effects of systemic retinoid therapy in patients with severe psoriasis // Saratov Journal of Medical Scientific Research, Vol. 9, Issue 3, 2013, pp. 549-552