Purpose: to study the dynamics of plasma hemostasis in women with uncomplicated pregnancies and with the manifestations of thrombophilia in the III trimester of pregnancy to the onset of delivery and the postpartum period. Materials and methods. Study of plasma parameters of hemostasis has been performed in 408 women. The surveyed patients have been divided into groups: A — Women with no abnormalities of hemostasis (n=152), В —Women with symptomatic thrombophilia (n=256). The women have been examined for the first time in the III trimester of pregnancy 38-39 weeks' gestation, 3 hours after birth and on the fifth day. Results. Women with thrombophilia have suffered significant changes in coagulation potential, characterized by hypercoagulability, thrombinemia and reduced reserve of natural anticoagulants, as well as decreased activity of fibrinolysis. The changes observed in the prenatal period, have intensified on the first days after birth. Conclusion. The indices can be used for control the risk of thrombogenic complications, rationale for therapy.