Aims. The study aimed an identifying of signs of the vegetative nervous system and detailed study of the psychological characteristics of patients with rosacea. Materials and methods. The study included 60 patients with different clinical forms of rosacea at the age from 26 to 56 years and a control group of 60 relatively healthy persons. The assessment of emotional status is carried out with the survey, Test of accentuations of temperament, Diagnostic Questionnaire Quality of Life Index (DILQ), The Zung Self-Rating Depression Scale, reduced multifactorial questionnaire for the study of personality. Vegetative nervous system was investigated using vegetative Kerdo index, Wayne and Solovyova tables and a special questionnaire for signs of vegetative disorders. Conclusions. Syndrome revealed the presence of vegetative-vascular dysfunction in patients with rosacea with a predominance of parasympathetic tone of the autonomic nervous system. Severity of psychoemotional disorders had no direct relationship to the severity of rosacea. But patients with advanced disease had a tighter self-control on the background of increased excitability and stronger internal emotional stress. Those patients were compared with a group of patients with earlier stage disease, which may provoke functional impairments and in case of long existence-the formation of psychosomatic disorders. This comprehensive assessment of vegetative and emotional status is included in the algorithm for evaluation of patients with rosacea and will successfully complement traditional therapy.