Aims. The present research aimed the study of the fuorescence of endogenous porphyrins of the skin in patients with acne. Material and methods. 20 patients with acne of 1 – 2 degrees of severity were selected. The main research methodology was a selective colorimetry of tissues with using an electronic photographic devices. The research was led with the use of multiple flters. Image areas were synthesized with high fuorescence, and then a combination of these areas with the source image was produced. The images were processed in ImageJ. Results. The examined patients has revealed intensive red glow in the feld of acne-elements before treatment. After the work with an orange flter pictures were more informative. The study suggests that the chosen method for identifcation of quantitative composition of P. acne appears to be noninvasive and highly effcient.

The study aimed to research an effciency and safety of isotretinoin usage in small doses in patients with recurrent acne of moderate severity. Materials and methods 40 patients (18 – 27 years) with acne were examined (25 women). All of the patients have had different therapy earlier. To estimate the severity and prevalence of the disease Acne Dermatology Index (ADI) was used. All the patients were ordered isotretinoin (Roaccutane) at a standard dose of 10 mg per day for 3 months. Concentrations of triglycerides, cholesterin, ALT and AST in blood serum have been researched before and during the isotretinoin therapy. After 3-months isotretinoin monotherapy there was a prospective 6-months observation. There have been 40 healthy people examined in a control group. Results. After 3 months of isotretinoin therapy comedones, papules, pustules disappeared in most of the patients, ADI ran to 0,6±0,01 (р<0,001). Isotretinoin in the whole is tolerable, side effects were minimal. By the end of a 3-months therapy laboratory ranges (AST, ALT, triglycerides, etc.) have become comparable with control parameters. Conclusion. Small doses of isotretinoin can quickly solve the problem of an eruption in patients with acne of moderate severity, prevent a recurrence, minimize side effects risk.