The goal of the research was the comparative analysis of headache clinical implications and ultrasonographic characteristics at women and men with dyscirculatory encephalopathy (DE). 72 women (middle age 64.3) and 48 men with dyscirculatory encephalopathy (DE) of l-ll stage comparable to their age (middle age 65.0) have been examined. The examinations were organized using diagnostic criteria of the International classification of headache disorders (ICDH — II, 2003), headache diary and the McGill Pain Questionnaire. Headache intensity was estimated bythe Visual Analog Scale. Cerebral hemodynamics changes were examined by means of duplex ultrasound of cerebral great vessels and transcranial duplex scanning. The comparative analysis revealed the predomination of tension-type headache among women with DE. They also surpassed men-patients in the indicators of headache intensity, attack duration and frequency. With the help of transcranial duplex scanning (TCDS)was revealed that women with headache were characterized by more severe abnormal venous outflow from the brain. The received data may be important for individualiza-tion of therapeutic approaches at men and women with headache and DE.