Objective: To determine sensitive and objective criteria of nephrosclerosis by testing the levels of markers of inflammation (MCP-1), fibrogenesis (TGF-(31), renal parenchymal damage (collagen type IV, a-GST, тт-GST), angiogenesis (VEGF) in urine of children with vesicoureteral reflux (VUR). Materials and methods: 80 patients with different stages of VUR have been observed before and 6 months after treatment. Results: «Index of early renal damage» can be found as correlation between VEGF and collagen type IV concentration. Conclusion: Estimation of «index of early renal damage» could be included in pediatric practice for the control of urinary tract dysfunction in children with VUR
Lakomova D.Yu. Index of early renal damage in children with vesicoureteral reflux // Saratov Journal of Medical Scientific Research, Vol. 8, Issue 2, 2012, pp. 318-324