The purpose of the article is to identify patterns of change in the properties of biocompatible coatings during modernization of its structure by changing the morphology and crystallinity of the starting powder particles of hydroxyapatite (HA) for agglomeration and subsequent grinding. Material and methods. We investigated the morphology, degree of crystallinity and internal tension in HA powder with a particle size of 40-90 microns in the initial state and after the agglomeration process and structure piasmasprayed HA coatings application methods ray analysis (XRF and XRD) on DRON-3, infrared spectroscopy (FT-IR spectrometer Nicolet 6700), optical (MIM-8) and atomic force microscopy (SMM-2000), the laser microprobe (Spectrum 2000). Results: It was shown that change in particle morphology HA agglomerated and subsequently grinding increases the uniformity of the porous structure, its crystallinity, reduce internal stresses developing surface morphology of the coating and its nanostructuring. Conclusion. It is recommended for the improvement of characteristics of the porous structure (uniformity, strength, adhesion), and the surface morphology of implant to use agglomerating starting powders and their subsequent grinding.
Melnikova I.P., Lyasnikova A.V., Lyasnikov V.N. Particle morphology of hydroxyapatite and its influence on the properties of biocomposite plasma coatings // Saratov Journal of Medical Scientific Research, Vol. 9, Issue 3, 2013, pp. 441-445

The article deals with topical issues of development, production and application of modern biocompatible materials and coatings based on them to clinical practice. Particular attention is paid to the intraosseous dental implants, which considered to be the most popular and well established methods to address the defects of dentition with partial and fully edentulous state.
Lyasnikov V.N., Lepilin A.V., Protasova N.V. Scientific fundamentals for the development of dental implants // Saratov Journal of Medical Scientific Research, Vol. 9, Issue 3, 2013, pp. 431-434

A single-stage innovative method of nano-sized hydroxyapatite Ca5(PO4)3OH (grain size equal 80 nm) synthetizing from aqueous solution was developed. This method is based on interaction between phosphoric acid solution and calcium nitrate in conditions, which are identical to conditions of hydroxyapatite formation in human organism. Structural and thermalphysic investigations of the compound were carried out using methods of high-temperature X-ray diffraction and differential scanning calorimetry. A big isomorphic capacity of apatite structure let us to suggest a number of chemical-modified hydroxyapatite creating ways. These modifications include such substitutions like “phosphorus-silicon”, “calcium-lanthanides”, “hydroxyl-fluorine”. Particularly hydroxyapatite doped by rare-earth elements can be used as an environmentally acceptable luminescent material. Isothermal batch reactor for a commercial production of hydroxyapatite was designed. Optimal conditions for the creating of hydroxyapatite-based bioceramic with controllable volume porosity were selected. Produced ceramic samples can be used in medical techniques for example in bone tissue engineering. Several steps of preclinical test were successfully passed. A new hybrid material which can be represented as high-porous hydroxyapatite ceramic impregnated with degradable polymer (chitosan) was obtained and its strength properties were investigated. For the first time the method of obtaining of hydroxyapatite whiskers (one-dimensioned dislocation-free crystals) using scheme “vapor-liquid-solid” was worked out. These whiskers can be used as a filling compound in composite materials. An improvement of hydroxyapatite sputtering on metallic and ceramic surfaces technique is also one of the most interesting areas of investigations.
Proceedings of the 2nd International Seminar on Chemistry. – 2011. – P. 47-50.