The purpose of the work is to prescribe combined treatment in order to determine the efficiency of cycloferon liniment. Materials and methods. 80 patients suffering from such inflammatory disease of parodentium as herpetic stomatitis and periodontitis have been examined and treated. Results. Cycloferon liniment used in the combined treatment of stomatitis and periodontitis reduces the infection load in gingival pockets, decreases local inflammation, normalizes immunity parameters, decreases endotoxemia and reduces relapse rates. Conclusion. Cycloferon liniment is an efficient medication restoring the parameters of local nonspecific immune response.
Soboleva L.A., Bulkina N.V., Shuldyakov A.A., Pospelov A.N. New approaches to therapy of oral inflammatory diseases // Saratov Journal of Medical Scientific Research, Vol. 9, Issue 3, 2013, pp. 467-469

The research goal is to investigate mechanisms of formation and course of herpetic stomatitis in patients with focal chronic tonsillitis. It has been established that patients with stomatitis and tonsillitis are able to develop local inflammatory reaction. It is accompanied by increase of infectious severity and activation of anti-inflammatory cytokines in fluid of parodontal pockets. It has been also proved that the cause factor of frequent and long relapses of stomatitis in patients with tonsillitis is due to the development of pathological process as a result of disbalance of lipid peroxidation and antioxidant system, endotoxicosis syndrome.
Khlamova O.G., Shuldyakov А.А., Lepilin A.V., Satarova S.A. Herpetic stomatitis development mechanism in patients with tonsillitis // Saratov Journal of Medical Scientific Research, Vol. 8, Issue 1, 2012, pp. 116-118

The research goal is to determine the clinical and pathogenetic efficacy of Cycloferon liniment in the combined therapy in patients with herpetic stomatitis accompanied by chronic tonsillitis. Materials and methods: Medical examination and treatment of 60 patients have been carried out. The marker of endogenous intoxication, infectious severity and immunity has been investigated. Results. It has been established that use of Cycloferon liniment in the combined therapy in patients with herpetic stomatitis accompanied by chronic tonsillitis has allowed to decrease infectious severity in par-odontal recess and evidence of local inflammation, to normalize immunity indices and reduce the level of endogenous intoxication that has been liable for acceleration of recuperation processes and lowering of frequency of stomatitis recurrences. Conclusion. The clinical efficacy of Cycloferon liniment in the therapy in patients with herpetic stomatitis accompanied by chronic tonsillitis conditioned by the decreasing of activity of local inflammatory process according to the reducing of level pro-inflammatory cytokines, infectious burden of the mouth cavity, endogenous intoxication
Shuldyakov A.A., Khlamova О.G., Lepilin А.V., Tsareva T.D. Improvement of herpetic stomatitis therapy in patients with chronic tonsillitis // Saratov Journal of Medical Scientific Research, Vol. 7, Issue 4, 2011, pp. 919-922