The article presents a detailed review on epidemiology, pathogenesis and interrelation of serotonin neuromedia-tor metabolism in the central nervous system in state of chronic pain and depression. It has been demonstrated that neurophysiological conditions serve as psychological defense of an individual. That mechanism has been proved to «transform» serious emotions onto the inner level (body) and it assists in the development of psychosomatic disorders — chronic pain syndrome
Chernus N.P. Chronic pain: Model of psychosomatic disorder (review) // Saratov Journal of Medical Scientific Research, Vol. 7, Issue 4, 2011, pp. 887-893