Найдено научных статей и публикаций: 2, для научной тематики: Genetic polymorphism
1.
Bulat A. Bakirov, D.O. Karimov, T.V. Viktorova
- Russian Open Medical Journal , 2012
The objective of the research is to study the role of polymorphic gene variants of Tumor Necrosis Factor-α (TNFA), Bcl-2-associated X protein (BAX), p53 Binding Protein (MDM2), vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in the development of chronic lymphocyt...
The objective of the research is to study the role of polymorphic gene variants of Tumor Necrosis Factor-α (TNFA), Bcl-2-associated X protein (BAX), p53 Binding Protein (MDM2), vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in the development of chronic lymphocytic leukemia (CLL).
Methods: The comparative analysis of allele and genotype frequency distribution in CLL patients (N=133) and healthy individuals (N=196) from Bashkortostan Republic has been carried out.
Results: Analysis of distribution of genotype and allele frequencies of the genes under study has shown that patients with CLL were likely to demonstrate an increased frequency of GG-genotype and G-allele of polymorphic locus-308G>A of TNFA gene, GG-genotype and G-allele of the polymorphic locus-248G>A of BAX gene, G-allele of the polymorphic locus 309T> G of MDM2 gene and allele C of polymorphic locus 773C>T of bFGF gene.
Bulat A. Bakirov, D.O. Karimov, T.V. Viktorova Polymorphism of apoptosis regulatory and growth factor genes in patients with chronic lymphocytic leukemia // Russian Open Medical Journal, Vol. 1, Issue 1, 2012, pp. 101-0
2.
Bakirov В.A., Karimov D.O., Viktorova T.V.
- Saratov Journal of Medical Scientific Research , 2011
The objective of the research is to study the role of polymorphic variants of Tumor Necrosis Factor (TNF) — a (TNFA), Bcl2-associated X protein (BAX) p53-Binding Protein (MDM2), vascular endothelial growth factor (VEGFA) and basic fibroblast growth factor (bFGF) genes in chronic lymphocytic leukemia...
The objective of the research is to study the role of polymorphic variants of Tumor Necrosis Factor (TNF) — a (TNFA), Bcl2-associated X protein (BAX) p53-Binding Protein (MDM2), vascular endothelial growth factor (VEGFA) and basic fibroblast growth factor (bFGF) genes in chronic lymphocytic leukemia (CLL). Methods: The comparative analysis of alleles and genotypes distributions in CLL patients (N=133) and healthy individuals (N=196) from Bashkortostan Republic has been carried out. Results: Analysis of the distribution frequency of genotypes and alleles of the genes studied has showed an increase in frequency of genotypes GG and allele G polymorphic locus-308G> A TNFA gene, GG and allele G of the polymorphic locus-248G>A BAX gene, allele G of the polymorphic locus 309T> G gene MDM2 and allele С polymorphic locus 773C>T bFGF gene in patients with CLL
Bakirov В.A., Karimov D.O., Viktorova T.V. Polymorphism of regulators of apoptosis and growth factors genes in chronic lymphatic leukemia // Saratov Journal of Medical Scientific Research, Vol. 7, Issue 4, 2011, pp. 827-831