Investigated biochemical changes in an oral liquid of patients with the extented chronic periodontitis chronic in aggravation stage, specific features of change of activity of enzymes of a mouth at presence fluoroquinolones , in the presence of the expressed inflammatory process in periodontium are revealed. The studied biochemical mechanisms of action of preparations can serve as criterion of a choice of the optimal preparation that will allow to improve essentially results of treatment of the given category of patients
Guseva O.U., Bulkina N.V., Osipova J.L., Kropotina A.Yu., Albitskaya J.N. Substantiation of the differentiated approach to the therapy by antibiotics at an aggravation of the extented chronic periodontitis // Saratov Journal of Medical Scientific Research, Vol. 7, Issue 1, 2011, pp. 287-288

We propose a new approach to predict functional specificity of proteins from their amino acid sequences. Our approach is based on two things: structural Multilevel Neighborhoods of Atom (MNA) descriptors and an original Bayesian algorithm. Usually, a protein sequence is presented as a string of amino acid symbols. Here we introduce a new description of an amino acid sequence: a set of structural MNA descriptors. The MNA descriptor is a string describing an atom and its neighbor atoms according to the selected level. In this work, we also use description of a protein sequence as a set of peptides (strings of amino acid symbols). We performed a case study on two subsubclasses of enzyme nomenclature (EC). It is shown that B-statistics give a sufficient predictive power of enzyme specificity prediction for both MNA descriptors and peptides. We also showed that MNA descriptors give higher accuracy values in comparison with peptides and also provide a choice of MNA descriptor levels for best accuracy prediction. The highest average accuracy prediction that was achieved was 0.98.
OMICS: A Journal of Integrative Biology, 2006, 10 (1), 56-65.

This review focuses on some intermediate results on the path from the gene and enzyme structure to physiological responses and personalised medicine. Bioinformatics of genetic and protein-structural polymorphisms, theoretical methods of predicting the influence of single amino acid substitutions on the structure and catalytic activity of enzymes are considered. For a large group of enzymes, interrelations between genetic modifications, structural changes of the proteins and the detected physiological and clinical manifestations are discussed. In this respect, highly productive techniques to determine the catalytic activity of an enzyme as well as non-invasive proteomic approaches are of particular interest. A non-invasive proteomic analysis using mass-spectrometric protein identification of human exhaled breath condensate and tear fluids has been chosen.