The purpose of the work is to research siofor influence (metformin) on the activity of the process of lipid peroxidation and antioxidant activity of blood serum at patients with metabolic syndrome. Material and Methods — 62 patients with metabolic syndrome at the age from 30 till 60 were examined and treated by siofor (1700 mg per day) during a year. The process of lipid peroxidation was studied due to the level of lipid hydroperoxide of blood serum. Antioxidant capacity was based on the antioxidant reaction in the blood serum with definite number of exogenic hydrogen dioxide (mkmole/l) with the method of enzyme-linked immunosorbent assay (ELISA). Results — Intensification of process of lipid peroxidation has been observed at patients with metabolic syndrome — the level of lipid hydroperoxide of blood serum has been 2.9 (1.9, 3.9) mkM (presented as median and interquartile range), antioxidant activity of blood serum has been decreased — 276.4 (239.0, 379.9) mkmole/l. In 12 months of siofor intake hydroperoxide level has been decreased till 1.1 (0.8, 1.9) mkМ, but antioxidant activity has been increased and amounted 320.0 (278.9, 334.3) mkmole/l. Conclusion — Siofor has been proved to be a highly effective medicine for correction of process of lipid peroxidation and for improvement of antioxidant activity of blood serum at patients with metabolic syndrome.
Elena N. Chernysheva, T.N. Panova Siofor influence on the process of lipid peroxidation and antioxidant status at patients with metabolic syndrome // Russian Open Medical Journal, Vol. 3, Issue 4, 2014, pp. 402-0

Purpose. The study of some indices of the metabolism in patients with the exacerbation of extensive psoriasis, the investigation of the revealed disorder dependence on the clinical peculiarities of the disease and anamnesis data. Methods. 253 patients with extensive psoriasis from the age of 18 to 72 have been investigated.Some indices of lipid and protein metabolism, medium molecular peptide content, lipid peroxidation and antioxidant protection processes in blood plasma have been studied. Results. Dysproteinemia, the increase of С — reactive protein level, seromucoid, medium molecular peptides, common lipids, triglycerides, the reduction of the level of lipid proteins of high density, the intensification of lipid peroxidation processes and the reduction of antioxidant activity have been marked in blood plasma in patients with the exacerbation of extensive psoriasis. The dependence of some indices of metabolism on the clinical picture and the severity of skin process, age, family history has been revealed. Conclusion. Metabolism disorders in patients with psoriasis are of systemic character. It seems appropriate to carry out a deep study of metabolism indices in patients with psoriasis with the following correction of the revealed disorders
Baityakov V. V. The peculiarities of the metabolism processes in patients with the exacerbation of extensive psoriasis // Saratov Journal of Medical Scientific Research, Vol. 7, Issue 3, 2011, pp. 633-636