Application of immunomodulatorGepon in treatment of aggressive periodontitis provides the normalization of cyto-kine balance of periodontal pockets exudate by raising the level of anti-inflammatory cytokines (IL-1(3, IL-8, IFN-y) and osteoprotegerin, indirectly confirming the improvement of bones of alveolar processes of jaws, as well as by significant decrease in the concentration of proinflammatory cytokines (IL-4, IL-10) and transforming growth factor (3. Gepon application improves the efficiency of preoperative period, accelerates postoperative rehabilitation of patients and helps achieve remission period up to 6 months in 71 % of cases, which is in 28% higher than in patients receiving traditional treatment
Vedyaeva A.P., Bulkina N.V., Smirnov D.A., Zakharova N.B. Optimization of complex treatment of aggressive peri-odontitis using immunocorrecting therapy // Saratov Journal of Medical Scientific Research, Vol. 7, Issue 2, 2011, pp. 485-490