Psoriasis is a common skin disease in which the development of the decisive role played by genetic and environmental factors. Many of the candidate genes linked with psoriasis, are directly related to acquired or congenital defects of the immune system, epithelial barrier permeability of the intestinal wall, and the keratinocyte membrain. Formation of an immune response to Th-1 type high expression and activity of antimicrobial peptides like state at their potential infection. This review discusses the possible immune mechanisms are involved in the relationship between infection and disease process in psoriatic skin. We survey the literature and discuss the suitability of infection factors in treatment modality for psoriasis.
Slesarenko N.A., Utz S.R., Kulaev K.A., Resnikova M.A., Panina L.V., Popova O.V. The role of infectious stimulus in the initiation and immune inflammation in psoriasis // Saratov Journal of Medical Scientific Research, Vol. 10, Issue 3, 2014, pp. 530-537

The article presents possible molecular mechanisms for rosacea pathogenesis from current domestic and foreign clinical observations and laboratory research: regulation and expression defects of antimicrobial peptides, vascular endothelial growth factor, the effect of serine proteases, oxidative stress, reactive oxygen species and ferritin on the occurrence and course of rosacea. New developments in molecular biology and genetics are advanced for researching the interaction of multiple factors involved in rosacea pathogenesis, as well as providing the bases for potentially new therapies.
Davydova A.M., Bakulev A.L, Morrison A.M., Leonova M.A. Molecular mechanisms of rosacea pathogenesis // Saratov Journal of Medical Scientific Research, Vol. 9, Issue 3, 2013, pp. 561-565

This review deals with antimicrobial peptides (AMPs) that demonstrate antibacterial, antiviral, and antifungal activity. It considers structure and mechanism of AMP interaction with lipid membrane and intracellular targets of pathogens. Special attention is paid to modern state and perspectives of AMP practical application and also to approaches that increase efficacy and reduce toxicity of AMP by chemical modification of their structure.
Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry, 2011, Vol. 5, No. 2, pp. 95–102.