Age-related changes in concentrations of the major connective tissue macromolecules – collagen, elastin, separate fractions of glycosaminoglycans – hyaluronic acid, chondroitin sulphates, heparan sulphate, and dermatan sulphate, as well as their proportion in both the skin and aorta were studied. An age-related increase of collagen content in both the skin and aorta and at the same time a decrease of elastin content were shown in these tissues. The content of hyaluronic acid, chondroitin sulphates, heparan sulphate and dermatan sulphate increases in the skin with age. Contrarily, in the aorta, a decrease in concentrations of hyaluronic acid and dermatan sulphate takes place with age, while those of chondroitin sulphates and heparan sulphate increase.
El-Ta’alu A.B., Kot Yu.G., Falchenko K.V., Persky Ye.E., Ponomarenko A.N. Age-associated changes in the content of collagen, elastin and glycosaminoglycans in rats’ skin and aorta // Вісник Харківського національного університету імені В.Н.Каразіна. Серія: біологія. – Харків. – Випуск 7 (№814). – 2008. – с. 26 – 29.