The research objective consisted in increase of efficiency of treatment sick ChRAS by inclusion in complex treatment of an immunomodulator of Gepon. Under supervision there were 18 patients at the age from 15 till 55th years, mainly women (70 %), with prescription of disease from one year (four patients) till 20th years (five patients). The data obtained by us says that application Gepon in complex treatment ChRAS considerably accelerates epithelization of ulcers, reduces congestion and a hypostasis of a mucous membrane of an oral cavity and reduces painful sensations
Bulkina N.V., Meleshina О.М, Lomakina D.O. Chronic recurrent aphthous stomatitis: clinical course and complex treatment // Saratov Journal of Medical Scientific Research, Vol. 7, Issue 1, 2011, pp. 281-282

Application of immunomodulatorGepon in treatment of aggressive periodontitis provides the normalization of cyto-kine balance of periodontal pockets exudate by raising the level of anti-inflammatory cytokines (IL-1(3, IL-8, IFN-y) and osteoprotegerin, indirectly confirming the improvement of bones of alveolar processes of jaws, as well as by significant decrease in the concentration of proinflammatory cytokines (IL-4, IL-10) and transforming growth factor (3. Gepon application improves the efficiency of preoperative period, accelerates postoperative rehabilitation of patients and helps achieve remission period up to 6 months in 71 % of cases, which is in 28% higher than in patients receiving traditional treatment
Vedyaeva A.P., Bulkina N.V., Smirnov D.A., Zakharova N.B. Optimization of complex treatment of aggressive peri-odontitis using immunocorrecting therapy // Saratov Journal of Medical Scientific Research, Vol. 7, Issue 2, 2011, pp. 485-490