The electrochemical behavior of brass in natural seawater in the absence and presence of oxadiazole derivatives, namely 2,5-bis-(4-aminophenyl)-1,3,4-oxadiazole (BAPOD), 2,5-bis-(4-bromophenyl)-1,3,4- oxadiazole (BBPOD), 2,5-diphenyl-1,3,4-oxadiazole (DPOD), and 2,5-bis-(4-nitrophenyl)-1,3,4-oxadiazole (BNPOD) has been investigated by potentiodynamic polarization and electrochemical impedance spectroscopy (EIS). The inhibition efficiency of the inhibitors was also evaluated at different temperatures. The inhibition efficiency was found to increase with increase in concentration of the inhibitors but decrease with rise in temperature for all the inhibitors except BNPOD. Inductively coupled plasma atomic emission spectroscopic (ICP-AES) analysis confirmed that dezincification was minimized to a greater extent in the presence of the inhibitors. Scanning electron microscopy (SEM), energy dispersive x-ray analysis (EDX) and Fourier transform infrared spectroscopy (FT-IR) observations of the brass surface confirmed the existence of an adsorbed film.