The purpose of the article is to identify the most characteristic and significant changes in indicators in patients with bladder cancer during diffusion-weighted whole-body imaging (DWIBS). Materials: From September 2009 till 2011 98 patients have been examined (61 (62,24%) with morphologically verified bladder cancer and 37 (37,76%) with cystitis. Results: The study has revealed that the sensitivity of DWIBS-study in detecting bladder cancer is 98,36%, specificity of 10,81 %, the efficacy of 65,38%. Conclusions: DWIBS is an informative noninvasive method for screening diagnostics of bladder cancer, to identify suspicious areas on regional, and distant metastases
Popkov V.M., Chekhonatskaya M.L., Zuev V.V., Ponukalin A.N., Nikolsky Y.E. Magnetic resonance diffusion-weighted whole-body imaging (DWIBS) in bladder cancer diagnostics // Saratov Journal of Medical Scientific Research, Vol. 7, Issue 4, 2011, pp. 941-946

The diagnostic significance of molecular markers was evaluated by immunohistochemical research of surgical and biopsy material of 106 patients with diseases of bladder and 57 patients with diseases of prostate. They received treatment at Scientific Research Institute of Fundamental and Clinical Uronephrology with monoclonal antibodies: Ki-67, PCNA, p63 (markers of proliferative activity), p53 (suppressor of tumor growth), Bcl-2, Bax (markers of apoptosis), EGFR (receptor of epidermal growth factors), PSA, PSMA, AMACR (prostate-specific antigens) and cytokeratin profile. The morphometric research was conducted on the basis of automated analysis system of digital images Ariol SL50 (Genetix)
Popkov V.M., Ponukalin A.N., Maslyakova G.N., Tsmokalyuk E.N., Bucharskaya A.B., Shirokov A.A., Burov A.M. Application of automated morphometric method of estimation of expression of immunohistochemical markers in diagnostics of prostate and bladder cancer // Saratov Journal of Medical Scientific Research, Vol. 6, Issue 4, 2010, pp. 845-849