Research objective: to study efficiency of diagnostic and preventive actions for decrease in frequency and weight of the retinopathy of the prematurely born (RPB), and also to carry out the analysis of incidence, the accompanying states and dynamic monitoring of prematurely born children with RPB. Material and methods. For 2 years it was surveyed on the retinal chamber "Ret Cam 3" — 531 patients of second stage of nursing Perinatal center of the Saratov region. Results. In 2013 from the examined 239 children, RPB is revealed at 56 (23,4%), 183 children (76,5%) had various changes of vessels of an eye bottom. In 2014 at 292 children the following ophthalmologic pathology was noted: incomplete development of vessels — at 101 (34,5%), an angiopatiya of vessels of a retina — 122 (41,8%), angiospasm — 18 (6,2%), a partial atrophy of disks of optic nerves at 3 (1,0%), an atrophy of eyeballs — 1 (0,3%), RPB is revealed at 47 (16,1 %). It is important to note that all children with the RPB malignant form had body weight at the birth less than 1000 grams and gestational age lower than 28 weeks. Conclusion. For the last year the tendency to decrease in cases of RPB including heavy forms, however spontaneous regress at initial stages of a disease was 12,4% lower, than in 2013 is noted.
Сhernenkov Yu.V., Nechaev V.N., Tereshenko V.A., Stasova Yu.V. Indices of retinopathy morbidity among premature children in Saratov region institutions of obstetrics // Saratov Journal of Medical Scientific Research, Vol. 11, Issue 4, 2015, pp. 553-555

Nursing of very low and extremely low birth weight infants is one of the most difficult problems of modern perinatol-ogy. It is impossible to carry out this task without organization of fee-ding of this group of children. The aim of our research was to study clinical efficiency of breast milk fortifiers administration (human milk fortifier) when preterm infants feeding. Materials and methods. In consequence of this clinical research (with included 60 premature infants born at less than 33 weeks of gestational age with less than 1500g birth weight) the following advantages before other types of feeding were revealed. Results. Mother and child solidarity in the course of breast feeding make deep favorable mutual emotional pressure. It was succeeded to keep all breast feeding advantages and to provide preterm infants special needs in feedstuffs. Human milk fortifiers administration provides higher body weight gain intensity; reduces length of stay in a hospital. It should not go unnoticed high tolerability and lack of complications at its medication usability was noted. Human milk fortifier divorce with small quantity of breast milk and that is especially important for very low and extremely low birth weight infants feeding. Conclusion. All above-mentioned allows recommending human milk fortifiers «PRE NAN FM 85» administration for breast milk in neonatal practice
Panina O.S., Chernenkov Yu.V., Arkhangelsky S.M., Prokopenko L.E. Experience in application of enriched breast milk in feeding children with very low birth weight // Saratov Journal of Medical Scientific Research, Vol. 10, Issue 4, 2014, pp. 623-626

Objective: to reveal and estimate dependence between a long waterless interval, infectious process at mother and pathology of newborn children. Material and Methods: Supervision and research have been carried out in Perinatal Center of Saratov region for the last 2 years. 167 women and 173 newborns were included in the research. The big group was composed by prematurely born children. Women were divided into 2 groups depending on infectious process of patrimonial ways and on duration of a waterless interval. Children were divided on gestation term. Results: fetoplacental insufficiency and threatened miscarriage are the main factors of extremely immature children birth. Under these conditions, prolongation of pregnancy and preparing a fetus to labor act are important factors for improving the adaptive capacity of a premature baby. One of the important factors of insolvency is membranes infection. It is a distinct disease or a result of complications of pregnancy prolongation in women with PROM, is a precursor of systemic inflammatory response and in the majority of newborns was realized in infectious process. Conclusion. Women with infectious pathology of birth canal should be thoroughly sanitized, preventive treatment should be carried out, it would prevent the implementation of fetus infection, reduce posthypoxic disorders and incidence of preterm birth and IUGR. Long PSU without infectious support contributes to a lesser extent implementation of infection in fetus and less effect on a child's neurological status.
Chernenkov Yu.V., Nechaev V.N., Lisitsyna A.S. Assessment of health state of newborns depending on duration of waterless interval and infectious process at mother // Saratov Journal of Medical Scientific Research, Vol. 10, Issue 3, 2014, pp. 427-431

The purpose of the article is to analyze the data of native and foreign literature and to consider the modern aspects of ultrasound diagnostics of premature birth, and new additional criteria for early diagnostics and prediction of preterm delivery. Hemodynamic characteristics in the second and third trimesters of the pregnancy have been covered.
Chekhonatskaya M.L., Vasilevich L.K., Petrosyan N.O., Kolesnikova E.A. Ultrasound Diagnostics of Premature Birth // Saratov Journal of Medical Scientific Research, Vol. 10, Issue 1, 2014, pp. 74-79

Purpose: to assess the factors having impact on physical development of prematurely born children at birth. Materials and Methods. 1099 case histories of newborns, the exchanged cards of pregnant women, birth case histories of women who gave birth in gestational age from 22 to 37 weeks. Results. It has been shown that there are significant indices effecting premature birth affect: chronic inflammatory diseases of the oropharynx, gastrointestinal tract, diabetes, thyroid disease, pathology of vision, infectious diseases, skin diseases; sexually transmitted infections, chronic pelvic inflammatory disease, cervical erosion, genital infantilism; preeclampsia of the first and second half of pregnancy, chronic fetoplacental insufficiency, anemia, inflammatory diseases during pregnancy, acute respiratory viral infections, obesity, gestational diabetes and pyelonephritis; prenatal pouring out of amniotic fluid, umbilical cord pathology, cho-rioamnionitis. Defined correlation between weight and height indicators of premature infants at birth and groups of medicines that women have during their pregnancy. Conclusions. Identification of factors affecting the level of physical development of premature children is important in determination of women with a higher probability of birth of children with intrauterine development and for assessing the further development of these children.
Vostrikova G.V., Ippolitova L.I., Pochatkov V.A., Popova I.N. Factors influencing the level of physical development of premature newborns // Saratov Journal of Medical Scientific Research, Vol. 9, Issue 4, 2013, pp. 714-719

Purpose: to establish the role of activation of lipid peroxidation and antioxidant deficiency of blood and amniotic fluid in the destabilization of membranes with early prenatal discharge of amniotic fluid. Material and methods. The analysis of lipid peroxidation products content in blood and amniotic fluid — diene conjugates (DC), malondialdehyde (MDA) and the quantitative determination of total peroxides (OxyStat), the estimation of the total antioxidant status (TAS), the activity of SOD and the content of ceruloplasmin in 20 pregnant with premature rupture of membranes in the gestation period of 22-34 weeks, were hospitalized at the Department of Pathology of Pregnancy of Saratov Perinatal Center in 2012. DC and MDA determination was carried out by conventional spectrophotometric methods of research, quantitative determination of peroxides (OxyStat) was carried out by enzyme immunoassay analyzer «Alfa Prime» («Meredith Diagnostics», 2008 using chemicals made by the company «Bender Medsystems»). The study of antioxidant status of serum and amniotic fluid was performed by enzyme immunoassay analyzer «Alfa Prime» («Meredith Diagnostics», England, 2008). Reagents («Bender Medsystems», Austria) were used to determine the total antioxidant status (TAS) and the SOD activity. To assess the content of ceruloplasmin reagent «Sentinel» (Italy) was used. Results. Indicators of lipid peroxidation in blood and amniotic fluid and anti-radical protection of biological membranes of cells and body fluids in the "mother-placenta-fetus" increased. Conclusion. Systemic activation of lipid peroxidation has been proved to be a pathogenetic factor in the failure of membranes in prenatal discharge of amniotic fluid. The increase in the blood levels of lipid peroxidation products on the background of the activation of antioxidant system is considered as a prognostic sign of abortion.
Mikhaylov А.V., Dyatlova L.I., Chesnokova N.P., Ponukalina Е.V., Glukhova T.N. Molecular and cellular mechanisms of destabilization of membranes and prenatal discharge of amniotic fluid // Saratov Journal of Medical Scientific Research, Vol. 9, Issue 4, 2013, pp. 644-648

The article analyses the modern state and the history of the extremely low birth-weight newborns problem. The specific medical characteristics of these newborns, connected with their morphofunctional immaturity, are presented. Definitions, diagnostics criteria and main sectors of medical care for patients with typical disorders of neonatal adaptation for this group are given. Substantial reasons for creating a complex program of early medical care are given, and the tasks of this program are formulated. Solving these tasks will provide safe survival of the extremely low birth-weight infants
Bochkova L.G. Eextremely low birth weight newborn // Saratov Journal of Medical Scientific Research, Vol. 6, Issue 3, 2010, pp. 640-646