The purpose of the research is to evaluate the clinical effectiveness of cyclosporine and other antihistamines in patients with chronic forms of urticaria resistant to basic first-line therapy. Open randomized controlled study has been performed in parallel groups. 53 patients with chronic idiopathic urticaria ages 18-50 years have been examined. In case of ineffectiveness of previous therapy, patients have been randomized into 2 groups: group I receiving cyclosporine (Sandimmune Neoral ®) 2,5 mg/kg/day, group II receiving cetirizine (Zyrtec ®) 10 mg/day and ranitidine (Zantac ®) 300 mg/day orally. It has been found that the administration of cyclosporine in patients with severe chronic idiopathic urticaria provides a more rapid achievement of clinical effect than the therapy with H1/H2 histamine antagonists. It is confirmed by a significant decrease of total index of severity of illness and major symptoms of skin lesions. This tendency towards normalization of quality of life of patients taking cyclosporine remains during 8 weeks after the medication. Thus administration of cyclosporine can be considered as therapy of choice in patients with chronic idio-pathic urticaria with a severe course and ineffective long-term therapy with antihistamines / systemic corticosteroids
V.I. Petrov, A.V. Razvalyaeva, S.A. Grebnev, N.V. Malyuzhinskaya Clinical efficiency of cyclosporine in chronic idiopathic urticaria in adults // Saratov Journal of Medical Scientific Research, Vol. 6, Issue 2, 2010, pp. 248-252