Найдено научных статей и публикаций: 1, для научной тематики: Deletion variant
1.
A.N. Nekrasov, L.E. Petrovskaya, V.A. Toporova, E.A. Kryukova, A.V. Rodina, E.Yu. Moskaleva, M.P. Kirpichnikov
- Biochemistry (Moscow) , 2009
Interleukin13 (IL13) is one of the cytokines involved in the development of Th2type immune response. It plays an important role in the pathogenesis of asthma and other allergic diseases. Two deletion forms of IL13 were constructed on a basis of informational structure analysis and expressed in E...
Interleukin13 (IL13) is one of the cytokines involved in the development of Th2type immune response. It plays an important role in the pathogenesis of asthma and other allergic diseases. Two deletion forms of IL13 were constructed on a basis of informational structure analysis and expressed in E. coli cells. They were found to differ in ability to stimulate proliferation of TF1 cell line. Deletion variant 146 (DV146) completely lacks such activity, whereas DV148 provides about 50% of the proliferation stimulation. The simultaneous addition of DV146 with fulllength IL13 suppresses proliferation depending on the concentration of the deletion form. Thus, the designed protein acts as an antagonist of IL13.
Biochemistry (Moscow), 2009, Vol. 74, No. 4, pp. 399-405.
