Seasonality of thrombogenic disorders in coronary atherosclerosis recrudescence has been studied using a comparison of blood clotting peculiarities in patients with stable (n=167) and unstable angina (n=210) in different season periods. It was established that there is no common mechanism for decompensation of hemostasis system in progressive angina. The structure of thrombogenic disorders is non-homogeneous. In winter the most important thing is an activating of prothrombinase producing, and in spring – reducing of heparin content and fibrinolysis activity inhibition. In summer thrombogenic changes are characterized by activating of intrinsic prothrombinase producing mechanism, antithrombin-III decreased activity and heparin content, fibrinolysis activity inhibition. In autumn an advanced euglobulin fibrinolysis block is enough to break the adaptation of hemostasis system.
Svetlana S. Parshina, Tatyana N. Afanasyeva, Liliana K. Tokaeva Seasonality of thrombogenic disorders in coronary atherosclerosis recrudescence // Russian Open Medical Journal, Vol. 1, Issue 2, 2012, pp. 205-0

Purpose. The purpose is to study the reaction of homeostasis system in stable and in distraction llizarov transosseous ostesysnthesis of the limbs bones at experimental animals (dogs) in highland conditions. Material and Methods. 63 adult mongrels aged from 1 to 3 years with 10-20 kg body weight and 15 cm minimal length of tibia were included in the experiment. Open osteosotmy of tibial mid-shaft followed by Kirschner wires insertion through tibial bone and llizarov frame assembly comprising 3 or 4 rings was performed under IV anaesthesia at 3200 m altitude above sea level. In experimental group including 33 mongrels the distraction was performed on the 5th day after osteotomy by 1 mm rate divided into 4 times within 10 days but in control group comprising 30 dogs the distraction was not provided. Every 10 days after distraction blood samples were taken in both groups to examine coagulation; the samples were taken from subcutaneous lateral tibial vein, ex tempora mixing with 3,8% solution of sodium citrate at 9:1 ratio. Then the plasma was separated and examined biochemically according to the accepted standards. Results. We obtained the data witnessing activation of coagulation component of homeostatic system in stable osteosynthesis of the limb bones using llizarov fixator with simultaneous inhibition of fibrinolytic component. In distraction osteosynthesis hyper-coagulation trend in homeostasis system with simultaneous suppression of fibrinolytic blood activity is vividly defined within the entire experiment period. Conclusion. Transosseous distraction osteosynthesis in highland condition causes considerable shifts in the system of homeostasis with definite domination of coagulation component which promotes formation of pre-thrombotic condition. Limb segment lengthening on the background of pre-thrombotic condition increases the risk of thromboembolic complications in highland conditions and requires appropriate measures of prophylaxis
Yerokhin A.N., Isakov B.D., Jumabekov S.A. Peculiarities of homeostatic system in highland conditions using llizarov distraction transosseous osteosynthesis method // Saratov Journal of Medical Scientific Research, Vol. 8, Issue 2, 2012, pp. 308-312

The present research is focused on defining the role of protein С system in the process of blood coagulation and fibrinolysis in patients suffering from different forms ofperiodontitis. The beginning of specific course of treatment in patients with chronic periodontitis there have been diagnosed disturbances in protein С system, the latter being the reason for blood coagulation disorders, such as: the decrease of protein С activity, the decrease of active factor Va resistance, the increase ofplasminogen reserve, the decrease of total antithrombin blood activity, antithrombin III activity including. The degree of changes in protein С system depends on the severity degree of chronic periodontitis: the more severe disease is the more severe disorders itcauses in protein С system. The most evident symptoms of depression of indices in protein С system were observed in patients with quick-progressive periodontitis. The decrease of protein С activity is caused by its consumption in the process of intravascular blood coagulation is characteristic periodontitis.
V.F. Kirichuk, T.V. Simonyan DISTURBANCES IN PROTEIN C SYSTEM IN PATIENTS SUFFERING FROM PERIODONTITIS // Saratov Journal of Medical Scientific Research, Vol. 4, Issue 1, 2008, pp. 48-51