Objective: to evaluate the influence of low-intensity electromagnetic fields on endogenous bioresonance therapy on the level of asymmetric dimethylarginine in blood, as well as on the parameters of microcirculation in the assessment of endothelial function in patients with chronic heart failure. Material and Methods. The basic group included 40 patients with chronic heart failure (NYHA II): 17 female and 23 male patients. The average age of the patients was 56,4±10 years. The control group consisted of healthy volunteers (20 patients, including 10 women, 10 men aged 31 ±5 years). Assessment of vasomotor state of the endothelium microcirculation was carried out with the help of laser Dopplerflow-metry on the apparatus LAKK-TEST (T) («Lazma», Russia). After the procedure endogenous bioresonance therapy was held. The intervention by low-intensity electromagnetic fields was carried out with the help of a hardware-software complex IMEDIS-EXPERT mode of endogenous bioresonance therapy for 15 minutes. Vasomotor endothelial function of microcirculation was evaluated. The concentration of an inhibitor of nitric oxide synthases, asymmetric dimethylar-ginine in blood before and after the exposure to the intervention by low-intensity electromagnetic fields was studied. Results. After the endogenous bioresonance therapy the microcirculation M parameter in the main group, on the background of iontophoresis with acetylcholine counted in average6,13±4,7 PF units. After iontophoresis with nitroprusside it was 5,9±3,8 PF units. In the control group the rate of myogenic oscillation amplitude (Am) amounted in average 0,75±0,13 Hz, in the main group it was 0,68±0,26 Hz. Reduction of myogenic tone in the control group was statistically significant (p<0,05). Conclusions. The results obtained have proved the positive influence of electromagnetic fields on endothelial function. The normalization of endothelium-dependentvasodilation marked the possibility of their participation in the production of nitric oxide.
Bokeria O.L., Kuular A.M. Influence of low-intensity electromagnetic fields on endothelial function in patients with chronic heart failure // Saratov Journal of Medical Scientific Research, Vol. 10, Issue 1, 2014, pp. 86-92

In the article the analysis of medical literature of changing in a vascular endothelium in psoriasis and type 2 diabetes in a combination is given.
Slesarenko N.A., Utz S.R., Shtoda U.M., Platonova A.N. Endothelial dysfunction in psoriasis and type 2 diabetes in terms of comorbidity // Saratov Journal of Medical Scientific Research, Vol. 9, Issue 3, 2013, pp. 590-595

Aim. To investigated endothelial dysfunction in patients with systemic lupus erythematosus (SLE), depending on different activity, duration of disease and different type of therapy. Methods. We examined 77 patients with SLE during 1 year. We administered puls therapy with high dose glucocorticoids and cyclophosphamide in the 33 patients. 44 patients were given low dose steroids orally or hydroxychloroquine. We investigated the number of circulating endothelial cells in peripheral blood. Vasoactive function was assessed in reactive hyperemia test, antitrombogenic function with short-lived ischemia was examined. Results. Patients with SLE demonstrated endothelial damage, its antitrombogenic and vasodilatation function was reduced especially in high activity of disease. Pulse therapy improved endothelial function after 12-month treatment periods. The activity of the SLE decreased what was associated with reduced endothelial damage. Also vasodilatation function improved, but anticoagulant activity was without changes. Conclusion. It is necessary to administer pulse therapy according to the right indication despite potential danger of steroids and cyclophosphamide on endothelial function. Probably pulse therapy should be used with vasoprotective drugs in order to improve anticoagulant function
Nam I.F., Rebrov А.Р. Features of endothelial dysfunction changes at patients with systemic lupus erythematosus on a background of various therapy// Saratov Journal of Medical Scientific Research // Saratov Journal of Medical Scientific Research, Vol. 7, Issue 4, 2011, pp. 822-827

The research goal is to study the connection between activity of systemic inflammation, endothelium damage and arterial rigidity in patients with psoriatic arthritis (PsA). Expression of arterial damage (the level of circulation of endothe-liocytes (CEC)) and indices of arterial rigidity have been studied in 32 patients with PsA. Methods used in the investigation are oscillography, photopletismography and occlusion test. Control group consisted of 22 practically in good health state volunteers. Patients with PsA had endothelium dysfunction, damage of endothelium and higher arterial rigidity. These findings were related to PsA activity and observed in patients with serious joint damage
А.Р. Rebrov, I.Z. Gaydukova Endothelium Damage And Arterial Rigidity In Patients With Psoriatic Arthritis // Saratov Journal of Medical Scientific Research, Vol. 5, Issue 4, 2009, pp. 544-548

The research goal is to determine the changes in concentration of both sVCAM-1 and VE-cadherin in blood serum of patients suffered from hemorrhagic fever with renal syndrome (HFRS). 87 patients aged 15-65 were examined. Concentrations of both sVCAM-1 and VE- cadherin in blood serum by means of "Bender MedSystems" (Austria) ELISA test were determined. It was shown that in both medium severe and severe forms of HFRS statistically the significant rise of sVCAM-1 concentration in blood with high indices in oliguric period took place. Complicated form was characterized by high indices of sVCAM-1 level in fever period, extremely decreasing in concentration in oliguric period and tendency to normalizing in clinical convalescence period. VE-cadherin level in blood was predominantly lower than control in all the observed groups with the exception of fever period in group with medium severe disease form. Negative correlation of normal intensity between adhesion molecules levels in blood was revealed. In conclusion it is necessary to point out that high VCAM-1 expression by endotheliocytes evidences the development of an adhesion form of endothelial dysfunction, low VE-cadherin production in a base for development of angiogenic form of endothelial dysfunction and changes in expression of these adhesion molecules that have adaptive metabolic response to macroorganism of HFRS pathogenic action
А.А. Baygildina Role Of Adhesion Molecules Vcam-1 And Ve-Cadherin In Endothelium Dysfunction Development At Hemorrhagic Fever With Renal Syndrome // Saratov Journal of Medical Scientific Research, Vol. 5, Issue 4, 2009, pp. 478-481

The purpose of the present work was to study questions connected with peculiarities of endothelial dysfunction in patients with gout Anticoagulant and fibrinolytic activities and activityofVillebrand factor were investigated. We have revealled endothelial dysfunction, which expressiveness decreased after 3-months treatmentin patients with gout
A.P. Rebrov, N.A. Magdeeva PECULIARITIES OF ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH GOUT AND ITS CHANGES DURING THE TREATMENT // Saratov Journal of Medical Scientific Research, Vol. 4, Issue 3, 2008, pp. 59-62

The aim of the given study was to define antithrombogenic and vasodilative vascular wall activity in patients with disturbed function of left ventricle (LV), developed after Q-myocardial infarction; and to specify its role in chronic heart failure (CHF) prognosis. 40 patients after Q-myocardial infarction were examined; compare five group consisted of 20 patients. Antithrombogenic (anticoagulant and fibrinolytic) and vasomotor activity of vascular wall were determined. It was revealed that disturbance of systolic function of left ventricle in patients with CHF is accompanied by decrease of antithrombogenic and vasodilative vascular wall activity. Patients with IV functional class of CHF having long term CHF and blood release value consisted < 33%; during six months of monitoring the number of repeated unfavourable cardiovascular events was essentially increased.
N.A Kosheleva, A.P Rebrov ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH DISTURBED MYOCARDIAL CONTRACTIVE ACTIVITY OF THE LEFT VENTRICLE IN CHRONIC HEART FAILURE PROGNOSIS // Saratov Journal of Medical Scientific Research, Vol. 4, Issue 2, 2008, pp. 76-81

The complex clinical and laboratory researches conducted in groups of the pregnant women with mild case of gestosis, middle serious preeclampsia and with heavys everity of gestosis. Anticoagulation and fibrinolytic activity of a wall of vessels on a background of creation of a short-lived ischemia were examined. Disturbance of a coagulative potential of a blood are actuated development endothelial dysfunction in groups of the pregnant women with middle serious preeclampsia and with heavy severity of gestosis.
G.I. Khripunova, E.V. Ponukalina, G.S. Salakhieva ABOUT THE ROLE OF ENDOTHELIAL DYSFUNCTION IN GESTOSIS DEVELOPMENT // Saratov Journal of Medical Scientific Research, Vol. 3, Issue 3, 2007, pp. 60-62