Research objective is to define the pathogenesis of varicous veins of small pelvis in women. at Ultrasonic investigation of venous system of small pelvis has been carried out in 290 pregnant women. It revealed 190 patients with varicose veins of small pelvis (VVSP). By means of V.M. Jakovleva's technique phenotypic menifestation of connective tissue dysplasia was determined in all pregnant women. Biochemical manifestations of connective tissue dysplasia were identified by sialic acid level in blood serum, daily excretion of glycosaminoglycans and oxyproline. High frequency of clinical and biochemical manifestations of undifferentiated forms of connective tissue dysplasia was revealed in pregnant women with VVSP. Patients with VVSP developed tooth and jaw, facial and locomotor damages. Patients with VVSP characterized by visceral undifferentiated forms of connective tissue dysplasia demonstrated by refraction involvement, ventral hernias, flat feet, varicous veins of lower extremities, hypermobile syndrome, mitral valve prolapse of different degree. Biochemical manifestations of undifferentiated forms of connective tissue dysplasia in pregnant women with VVSP were insignificant
N.M. Shibelgut, I.S. Zaharov, V.G. Mozes Clinical and biochemical manifestations of undifferentiated forms of connective tissue dysplasia in pregnant women with varicose veins of small pelvis // Saratov Journal of Medical Scientific Research, Vol. 6, Issue 1, 2010, pp. 56-60

To study the variants of the clinical course of varicose disease of patients with different grades of connective tissue dysplasia intensity. The results of the examination and treatment of 280 patients with various forms of varicose disease have been studied. The degree (grade) of connective tissue dysplasia intensity has been estimated. The values characterizing flow and coagulation properties of blood, functional activity of thrombocytes have been studied. Morphological, histological, histochemical check studies of extirpated varicose modified veins of patients with various grades of connective tissue dysplasia intensity have been held. The conducted check studies have shown that lower limbs varicose disease of patients with evident connective tissue dysplasia is characterized by early evidence of clinical signs, rapid advance of the disease, widely spread damage of veins and complicated course caused by the weakness of the connective-tissular carcass of a vein wall as well as by evident disorders of flow and coagulation properties of blood. Patients with varicose disease secondary to the evident (expressed) connective tissue dysplasia are in the risk group of palindromia, thrombus complications and trophesies development, need dispensary observation for proper treatment in good time.
А.А. Svistunov, О.А. Tsarev, G.N. Maslyakova, Yu.V. Mashchenko A Clinical Course of The Varicose Disease of Patients With Different Grades of Connective Tissue Dysplasia Intensity // Saratov Journal of Medical Scientific Research, Vol. 5, Issue 2, 2009, pp. 261-266