Aim: to determine the morphological and functional relationships between the morphometric parameters of lung airness tissue specimens of laboratory rats and indicators of physical endurance while swimming with weights and running on a treadmill. Material and methods. The physical endurance of laboratory rats evaluated in tests of swimming with weights and running on a treadmill using computer video markerless tracking. After strenuous exercise prepared histologic lung stained with hematoxylin and eosin. In morphometric study there were determined areal parameters of lung airness and pulmonary distelectasis. Results. When comparing the results of studies of physical endurance to the morphometric data of lung airness and pulmonary distelectasis identified the parameters of the same type of regression. Between changes in the morphological and physiological characteristics was a strong and average power correlation. The highest coefficient of correlation was established between the indicators of physical endurance and the parameter characterizing the degree of pulmonary distelectasis. Conclusion. Indicators of physical performance were the best in the big lung airness. At the same time, to a lesser extent than in the lung were presented wears off portions of the alveoli, the longer the biological objects to perform physical work. Fitted regression dependence characterizing the effect on physical endurance performance airiness of the lungs and spread them distelectasis.
Datsenko А.V., Kazmin V.I. Morphometric parameters of air in lungs of laboratory rats on physical exercise. // Saratov Journal of Medical Scientific Research, Vol. 11, Issue 4, 2015, pp. 645-649

Objective: to identify changes of the configuration and size of the walls of the alveolar stages of ontogenesis. Materials and Methods. Orthopantomograms studied 196 children aged 5 to 12 years. We used visual and morphometric methods. Results. The data on the three diameters of the dental alveoli (proximal, middle and distal) has been presented, under which subsequently the main stages of age transformation have been highlighted. Conclusion. Transformation of the alveolar walls radiologically determined and its advancing character in relation to the macroprocesses in the germ tooth have made it possible to consider alveolus as one of the leading biological tools of odontogenesis.
Okushko M.R., Suetenkov D.E., Chependyuk Т.А. Ontogenesis of the alveolar walls of the tooth germ according to orthopantomography // Saratov Journal of Medical Scientific Research, Vol. 11, Issue 4, 2015, pp. 561-565

Objective: to identify the microscopic features of the structure of the thyroid gland in different forms of its pathology. Materials and Methods. The study is based on the thyroid glands of 199 patients of both sexes aged 21 to 74 years. Results. At the micro-macrofollicular nontoxic goiter was found flattened thyroid epithelium with flattened normochromic nucleus, the small size of cells and nuclei, low nuclear-cytoplasmic index, intrafollicular moderate epithelial proliferation, homogeneous colloid and moderate diffuse lymphoid infiltration. At the micro-macrofollicular toxic goiter detected cubic epithelium with rounded normochromic kernel, smallest size of cells and nuclei, nuclear-cytoplasmic minimum index intrafollicular focal proliferation of the epithelium, colloid mesh boundary with severe vacuolization, focal lymphoid infiltration and hemorrhage. When diffuse toxic goiter detected cubic form cells of medium size with a fairly high nuclear-cytoplasmic index, rounded normochromic kernel, rare intrafollicular epithelial proliferation, homogeneous colloid with an edge vacuolization. With the prevalence of autoimmune thyroiditis was observed flattened epithelium with rounded normochromic nucleus, the small size of cells and nuclei, found the average nuclear-cytoplasmic index, homogeneous colloid and extensive lymphoid infiltration with light propagation centers. Adenoma of the thyroid gland epithelium was found with a cubic cell shape, round hyperchromatic nucleus, the large size of cells and nuclei, high nuclear-cytoplasmic index intrafollicular diffuse proliferation of epithelial and dense colloid. When thyroid cancer found the prevalence of papillary structures with short broad papillae formed polymorphic cells with round hyperchromatic nucleus, there is the largest size of cells and nuclei, nuclear-cytoplasmic maximum index expressed intrafollicular diffuse proliferation of the epithelium. Conclusions. Each form of thyroid disease, along with well-known typical microscopic manifestations is a characteristic regional feature of the microstructure.
Khayrullin R.M., Kalmin O.V., Kalmin O.O. The structure of thyroid gland in its pathology // Saratov Journal of Medical Scientific Research, Vol. 11, Issue 2, 2015, pp. 113-117

Purpose: the complete analysis of the morphological parameters of the thyroid gland in various forms of thyroid pathology by methods of mathematical modeling. Material and Methods. Histologically examined samples of operating thyroid glands of 199 patients of both sexes aged 21 to 74 years, were treated surgically. Experimental data were studied by factorial and discriminant analysis. Results. When the factor analysis of 60 experimental parameters were identified 14 major factors that indicate 14 main trends in the dynamics of the structure of the thyroid gland due to an increase in severity of pathological processes. Discriminant analysis showed that the study of quantitative structure of the thyroid gland there may be cases of erroneous inclusion in the theoretical option groups, however, the study of the entire set of indicators observed a 100% correct distribution of cases by groups of pathology. Conclusion. As a result, the factor of the original system of 60 morphological parameters of thyroid pathology in various forms has been minimized to 14 new uncorrelated parameters (main factors), reflecting changes in the morphology of the basic laws of the pathology of the gland. As a result of the discriminant analysis of morphological parameters of the thyroid gland in different types of its pathology the importance of semi-quantitative parameters of thyroid structure has been revealed.
Kalmin O.V., Kalmin О.О.. Mathematical modeling of structural indices of thyroid gland in thyroid pathology // Saratov Journal of Medical Scientific Research, Vol. 10, Issue 1, 2014, pp. 38-44

The purpose of the article is to assess the severity of the morphological changes in the internal organs of laboratory animals with prolonged oral administration of gold nanoparticles of different sizes. Material and methods: The experiment was carried out on 40 albino rats which were divided into 4 groups. Animals of the experimental group received oral gold nanoparticles by the appropriate scheme. Results: At comparing the morphological changes in the internal organs of laboratory animals it was established that the introduction of gold nanoparticles of different sizes leads to the same type of disturbances of morphological structure, the gold nanoparticles of 1-3 and 50 nm cause the most expressive changes. Conclusion: The most significant morphological modifications in the internal organs were caused by gold nanoparticles of 1-3 and 50 nm. It points out to the size-dependence of the effect of gold nanoparticles.
Maslyakova G.N., Pakhomiy S. S., Bucharskaya А.В., Zlobina O.V., Navolokin N.A., Ponukalin A.N., Khlebtsov N.B., Khlebtsov B.N., Bogatyrev V.A. Morphological changes in the organs of laboratory animals during the prolonged oral administration of gold nanoparticles // Saratov Journal of Medical Scientific Research, Vol. 9, Issue 2, 2013, pp. 208-213

The purpose was to reveal patterns of morphometric characteristics variability of lumbar vertebrae and sacrum for a choice of more adequate selection of standard sizes and introduction orientation of corrigent metalware at surgical treatment of spondylolisthesis. Preparations of lumbar vertebrae and sacrum of 60 skeletons, 110 Kt-grams of men and women of the first and second periods of mature age without visible pathology of a backbone and 300 Kt-grams of patients with spondylolisthesis. The data on age variability and sexual dimorphism of lumbar vertebrae and sacrum were obtained. The analysis of results of surgical treatment of 288 patients with spondylolisthesis during 1995-2008 was carried out. 160 patients were managed with preoperative planning, taking into account morphometric characteristics of vertebrae and sacrum since 2003. It is necessary to install and arrange metalware at reduction taking into account features of back structures and forward basic complex of lumbar vertebrae and sacrum; that allows to receive adequate decompression of neurovascu-lar structures in 85-90% cases, reliable correction and stabilization of damaged lumbosacral segments
Anisimova Е.А., Nikolenko V.N., Ostrovsky V.V., Toma A.I. Morphometric substantiation of a fixation method choice at surgical correction of spondylolisthesis // Saratov Journal of Medical Scientific Research, Vol. 6, Issue 3, 2010, pp. 678-683

CII arch fractures are divided into groups according not to anatomical localization, but to the instability degree resulted from the trauma. Effendi et al classification became greatly widespread. |t is based on the same stability criteria, but it is simpler, intelligible and gives the plan of treatment. All the fractures according to this classification are divided into three types: the first one consists in stable fractures in which even in functional images there is no any rough deformation at the level of CII segment; the second one consists in damages with significant angular (more than 11°) or shift (more than 3,5 mm) deformations, that indirectly indicates damage of soft tissue structures, and first of all diskoligamentous complex. The services of the authors of the present classification are also that they were the first who had defined fracture-dislocation of CII arch, attributed it to the third type. Choice of surgical procedure in unstable CII-III vertebral fractures is ventral spondylosyndesis of CII-III carried out by submaxillary approach after the preliminary closed elimination of deformation of upper cervical part of spine. The differentiated approach to the implant choice with an allowance for morphometric data allows to receive adequate decompression of nervous - vascular structures and reliable stabilization of the damaged segment
V.V. Ostrovskiy, V.G. Ninel, A.E. Shulga, A.A. Smoljkin, E.A. Anisimova Experience of surgical treatment of unstable СII vertebral fractures // Saratov Journal of Medical Scientific Research, Vol. 6, Issue 2, 2010, pp. 432-435

For the purpose of working out of the differentiated approaches to preoperative planning in each specific case on the basis of character estimation of spinal column and spinal cord damage 129 patients (112 men and 17 women) with subaxial damages in the cervical department of backbone have been examined. Morphological peculiarities of cervical vertebrae have been taken into account. The patients have been on treatment at Saratov Scientific Research Institute of Traumatology and Orthopedics from 2004 till 2007. Patients have been properly examined. Volume of surgical intervention from the frontal access and rational choice of implants have been carried out taking into account difficulty and extension of lesions of osseous structures, and morphometry data including in stabilization of vertebrae. The differentiated approach to the choice of implants has allowed in 85-90% cases to receive adequate decompression of neurovascular structures, reliable correction and stabilization of the damaged segment thus it has enabled possible early activization and social rehabilitation of patients of given category.
V.V. Ostrovsky, V.G. Ninnel, E.A. Anisimova MORPHOMETRICAL SUBSTANTIATION OF VENTRAL FIXATION USE IN SURGICAL REHABILITATION OF PATIENTS WITH SUBAXIAL DAMAGES OF CERVICAL DEPARTMENT OF SPINAL COLUMN // Saratov Journal of Medical Scientific Research, Vol. 5, Issue 1, 2009, pp. 100-103